Logistic Discriminant Analysis in Diagnosing Prostate Cancer Based on Chained Equation_West China Medical Journal

Authors：

ZHANG Wei ¹ , YUAN Jiaying ¹ , LI Yongzhong ² , LI Mei ³ , GOU Zhongping ³ ,  FENG Ping. ³

1. Department of Epidemiology and Biostatistics, West China School of Public Health; 2. Department of Ultrasound, West China Hospital; 3. National Clinical Trials Agencies, West China Hospital; Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

FENG Ping., Email: zhangwei19880404@163.com

Keywords：

鏈式方程; 多重填補; 前列腺癌; Logistic判別

DOI：

DOI: 10.7507/1002-0179.20130064

Video：

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目的　應用基于鏈式方程的填補方法處理醫學研究中的數據缺失，并以填補后完全數據構建聯合指標的logistic判別函數，判斷其在前列腺癌的預測診斷中的應用價值。方法　采用模擬研究，針對現實數據缺失情況模擬不同填補集結果，并以此對現實數據進行填補，以完整數據構建logistic判別，進行分析預測。結果　填補結果隨著填補次數的增加而逐漸接近真實值并趨于穩定。聯合年齡、血清前列腺特異性抗原值、血流阻力指數及經直腸前列腺超聲檢查指標的logistic判別分析結果的靈敏度為82.39%，特異度為74.86%。結論　聯合指標分析可提高前列腺癌的診斷預測水平，以減輕患者穿刺痛苦。

Citation： ZHANG Wei,YUAN Jiaying,LI Yongzhong,LI Mei,GOU Zhongping,FENG Ping.. Logistic Discriminant Analysis in Diagnosing Prostate Cancer Based on Chained Equation. West China Medical Journal, 2013, 28(2): 200-203. doi: DOI: 10.7507/1002-0179.20130064 Copy

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1. 　Little RJA, Rubin DB. Statistical analysis with missing data (Wiley series in probability and mathematical statistics)[M]. New York: Wiley John & Sons, 1987: 209-214.
2. 　Graham JW. Missing data analysis: making it work in the real world[J]. Annu Rev Psychol, 2009, 60: 549-576.
3. 　White IR, Royston P, Wood AM. Multiple imputation using chained equations: issues and guidance for practice[J]. Stat Med, 2011, 30(4): 377-399.
4. 　Lee KJ, Carlin JB. Multiple imputation for missing data: fully conditional specification versus multivariate normal imputation[J]. Am J Epidemiol, 2010, 171(5): 624-632.
5. 　Van Buuren S, Boshuizen HC, Knook DL. Multiple imputation of missing blood pressure covariates in survival analysis[J]. Stat Med, 1999, 18(6): 681-694.
6. 　Van Buuren S. Multiple imputation of discrete and continuous data by fully conditional specification[J]. Stat Methods Med Res, 2007, 16(3): 219-242.
7. 　Azur MJ, Stuart EA, Frangakis C, et al. Multiple imputation by chained equations:what is it and how does it work? [J]. Int J Methods Psychiatr Res, 2011, 20(1): 40-49.
8. 　Graham JW, Olchowski AE, Gilreath TD. How many imputations are really needed? Some practical clarifications of multiple imputation theory[J]. Prev Sci, 2007, 8(3): 206-213.
9. 　孫穎浩. 我國前列腺癌的研究現狀[J]. 中華泌尿外科雜志, 2004(2): 5-8.
10. 　Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J]. CA Cancer J Clin, 2013, 63(1): 11-30.
11. 　沈偉東, 查月琴, 王阿軍, 等. 經直腸超聲結合前列腺特異性抗原密度檢測對前列腺癌的診斷價值[J]. 蘇州大學學報(醫學版), 2008, 28(5): 811-813.
12. 　劉東亮, 盧一平. PSA 及其分子形式與PSAD、PSAV、PSAT在前列腺癌早期診斷中的應用[J]. 華西醫學, 2003, 18(4): 591-592.
13. 　何有華, 楊琰, 陳映鶴, 等. 前列腺內腺動脈血流阻力指數對評估良性前列腺梗阻的意義[J]. 中國中西醫結合外科雜志, 2008, 14(4): 323-325.
14. 　李永忠, 李響, 曾浩, 等. 經直腸超聲引導行會陰部穿刺前列腺活檢的臨床意義[J]. 華西醫學, 2008, 94(5): 998-999.
15. 　Kökeny GP, Cerri GG, de Oliveira Cerri LM, et al. Correlations among prostatic biopsy results, transrectal ultrasound findings and PSA levels in diagnosing prostate adenocarcinoma[J]. Eur J Ultrasound, 2000, 12(2): 103-113.

West China Medical Journal

Logistic Discriminant Analysis in Diagnosing Prostate Cancer Based on Chained Equation

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